|
KMID : 0370219980420050534
|
|
Yakhak Hoeji
1998 Volume.42 No. 5 p.534 ~ p.539
|
|
|
Embryo and Fetal Developmental Toxicity Study on Recombinant Human Epidermal Growth Factor ( rhEGF ) in Rats
|
|
박귀례/Park KL
한순영/신재호/이유미/박희성/장성재/Han SY/Shin JH/Lee YM/Park HJ/Jang SJ
|
|
|
Abstract
|
|
|
|
Effect of recombinant human epidermal growth factor (rhEGF, DWP401) on fetal external, visceral and skeletal malformation during organogenesis was examined. Pregnant Sprauge-Daw ley rats were administered with 0.2, 1 and 5mg/kg/day subcutaneously on gestation day 6 through 16. Dams were sacrified at 20th day of gestation. Materal body weight, food consumption and clinical observation were not changed. Significant dose-dependent increase of relative and absolute liver weight were observed in the treatment group, whereas other organ weights were not changed. Placental weight of 1 and 5mg/kg/day group and number of resorption in 5mg/kg/day treatment group were significantly increased. External and visceral malformation of fetuses were not observed with treatment. However, skeletal variations(increase of asymmetry sternebrae, decrease of dumb-bell and asymmetry sternbrae at 5mg/kg/day, and fused stemebrae at 5mg/kg/day) were observed. These results showed that rhEGF (DWP401) may not have embryo and/or fetal developmental toxicity effect in rats.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|